(R)-T-BINAP

(R)-T-BINAP

Asymmetric Synthesis, BINAPs, Chemical Synthesis, Chiral Catalysts, Ligands, and Reagents, Privileged Ligands and Complexes, BINAPs

(R)-T-BINAP is a versatile chiral organophosphorus ligand and has been used in several catalytic applications such as: 

1. Palladium catalyzed carbon-oxygen bond formation (Ref: J. Am. Chem. Soc., 1997, 119, 11108) 

2. Palladium-catalyzed α-arylation reaction of ketones (Ref: J. Am. Chem. Soc., 2000, 122, 6797)

3. Cu-catalyzed asymmetric conjugate reduction (Ref: J. Am. Chem. Soc., 1998, 120, 837)

4. Cu-catalyzed asymmetric dienolate addition to aldehydes (Ref: J. Am. Chem. Soc., 2003, 125, 11253)

5. Enantioselective conjugate reduction of lactones and lactams (Ref: Org. Lett., 2003, 5(20), 3691)

6. Enantioselective cycloaddition of allenylsilanes with α-Imino esters (Ref: J. Am. Chem. Soc., 2003, 125, 5644)

7. Catalytic Aldol reaction to ketones (Ref: Org. Lett., 2005, 7(22), 4955)

8. Rhodium catalyzed [2+2+2] cycloaddition reaction of alkenes and alkynes (Org. Lett., 2011, 13, 4692)

9. Copper-catalyzed asymmetric conjugate addition of alkyl Grignard reagents on α,β-unsaturated esters (Ref: Chem. Commun., 2010, 46, 8694) 

10. Copper-catalyzed asymmetric synthesis of cyclopropanes via tandem conjugate addition and intramolecular enolate trapping (Ref: J. Am. Chem. Soc., 2010, 132, 14349)

Note:  Please check notes for R-BINAP for additional applications