(R)-Styrene Oxide

(R)-Styrene Oxide

(R)-Styrene Oxide is an intermediate used to  produce a homologated epoxide as part of a synthetic approach to (+)-allosedamine

Reference :

1. Kang, B.; Chang, S. Tetrahedron 60, 7353-7353, (2004)
2. (R)-Styrene Oxide has several other applications: 
• Synthesis of 5-pyrimidyl alkanol
• Enantioselective synthesis induced by chiral epoxides in conjunction with asymmetric autocatalysis Kawasaki T, et al. Tetrahedron Asymmetry 15(23), 3699-3701, (2004)
• Stereoselective intermolecular O-alkylation of phenols with epoxides
• A new regio-and stereoselective intermolecular Friedel-Crafts alkylation of phenolic substrates with aryl epoxides Bertolini F, et al. Tetrahedron Letters 47(1), 61-64, (2006)
• Ring-opening reactions of epoxides with alcohols, carboxylic acids, and thiols
• Aluminumdodecatungstophosphate (AlPW12O40) as a reusable Lewis acid catalyst: Facile regioselective ring opening of epoxides with alcohols, acetic acid and thiols Firouzabadi H, et al. J. Mol. Catal. A: Chem. 250(1-2), 237-242, (2006)