(R)-Epichlorohydrin

(R)-Epichlorohydrin

(R)-Epichlorohydrin is a chiral API intermediate with several applications in the pharma industry including

1) Brivaracetam, an anticonvulsant

2) Lemborexant, for treatment of insomnia

3) Linezolid, an antibacterial drug

Other applications

4) Synthesis of a key intermediate in the synthesis of stable PGI2 analogue UT-15.

Ref: Robert M Moriarty et. al, The Journal of organic chemistry, 69(6), 1890-1902 (2004-4-3)

5) Synthesis of chiral morpholines and dioxanes via a Mitsunobu diol-cyclization

Ref: Goss S Kauffman et. al, The Journal of organic chemistry, 71(23), 8975-8977 (2006-11-4)

6) Enantioselective synthesis of trans-2,4-disubstituted piperidines

Ref: Alfonso Pérez-Garrido et. al, Bioorganic & medicinal chemistry, 16(10), 5720-5732 (2008-4-15)